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Article

Cholecystokinin responsiveness varies across the population dependent on metabolic phenotype.

The American journal of clinical nutrition - 1 Aug 2017

Desai Aditya J, Dong Maoqing, Langlais Blake T, Dueck Amylou C, Miller Laurence J

Abstract excerpt

Background: Cholecystokinin (CCK) is an important satiety factor, acting at type 1 receptors (CCK1Rs) on vagal afferent neurons; however, CCK agonists have failed clinical trials for obesity. We postulated that CCK1R function might be defective in such patients due to abnormal membrane composition, such as that observed in cholesterol gallstone disease.Objective: Due to the challenges in directly studying CCK1Rs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28592602
DOI: 10.3945/ajcn.117.156943
PMCID: PMC5525122

Genes

CCK

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