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Article

Endogenous Incretin Insufficiency in Obesity: Etiological Defect or Metabolic Maladaptation?

2026-04-21

Abstract excerpt

<title>Abstract</title> <p> <bold>Introduction:</bold> Obesity is associated with measurably attenuated postprandial incretin responses, characterized by blunted glucagon-like peptide-1 (GLP-1) secretion and functional resistance to glucose-dependent insulinotropic polypeptide (GIP) signaling. Whether this enteroendocrine dysregulation represents a primary pathophysiological defect anteceding adiposity or a sec...

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Literature Corpus work
f4309d98-2e10-5932-a706-65818321feaa
DOI
10.21203/rs.3.rs-9453154/v1
Open publication

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