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From one-size-fits-all to phenotype-based pharmacotherapy: How far are we in obesity management?

Current opinion in pharmacology - 1 Feb 2026

Koufakis Theocharis, Busetto Luca

Abstract excerpt

Obesity is a global health crisis, projected to affect over one billion adults by 2030. Lifestyle modification strategies-diet, physical activity, and behavioral therapy-have achieved only modest and often unsustainable outcomes. Pharmacotherapy has therefore emerged as a cornerstone of modern obesity care. Glucagon-like peptide-1 (GLP-1) receptor agonists and dual incretin agents such as tirzepatide have...

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PMID: 41371122
DOI: 10.1016/j.coph.2025.102589

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