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Article

Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity.

The Biochemical journal - 6 Jul 2017

Lorenz Robin, Moon Eui-Whan, Kim Jeong Joo, Schmidt Sven H, Sankaran Banumathi, Pavlidis Ioannis V, Kim Choel, Herberg Friedrich W

Abstract excerpt

Cyclic AMP and cyclic GMP are ubiquitous second messengers that regulate the activity of effector proteins in all forms of life. The main effector proteins, the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) and the 3',5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG), are preferentially activated by cAMP and cGMP, respectively. However, the molecular basis of...

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Identifiers

PMID: 28583991
DOI: 10.1042/BCJ20160969
PMCID: PMC5896744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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