Article
Distinguishing the roles of the two different cGMP-binding sites for modulating phosphorylation of exogenous substrate (heterophosphorylation) and autophosphorylation of cGMP-dependent protein kinase.
The Journal of biological chemistry - 7 Jan 2000
Smith J A, Reed R B, Francis S H, Grimes K, Corbin J D
Abstract excerpt
The role of each of the two different cGMP-binding sites (referred to as slow and fast sites) of type I cGMP-dependent protein kinase (PKG) in altering the rate of catalysis of phosphorylation of exogenous substrates (heterophosphorylation) or the rate of autophosphorylation has not been resolved. In the present study, the cGMP concentration required for half-maximal activation (A(50)) of wild-type PKG type Ibeta...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.