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Article

Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.

PLoS biology - 1 Jan 2015

Akimoto Madoka, McNicholl Eric Tyler, Ramkissoon Avinash, Moleschi Kody, Taylor Susan S, Melacini Giuseppe

Abstract excerpt

Protein Kinase A (PKA) is the major receptor for the cyclic adenosine monophosphate (cAMP) secondary messenger in eukaryotes. cAMP binds to two tandem cAMP-binding domains (CBD-A and -B) within the regulatory subunit of PKA (R), unleashing the activity of the catalytic subunit (C). While CBD-A in RIα is required for PKA inhibition and activation, CBD-B functions as a "gatekeeper" domain that modulates the control...

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Identifiers

PMID: 26618408
DOI: 10.1371/journal.pbio.1002305
PMCID: PMC4664472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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