Article
Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.
Science (New York, N.Y.) - 11 Aug 1995
Su Y, Dostmann W R, Herberg F W, Durick K, Xuong N H, Ten Eyck L, Taylor S S, Varughese K I
Abstract excerpt
In the molecular scheme of living organisms, adenosine 3',5'-monophosphate (cyclic AMP or cAMP) has been a universal second messenger. In eukaryotic cells, the primary receptors for cAMP are the regulatory subunits of cAMP-dependent protein kinase. The crystal structure of a 1-91 deletion mutant...
Topics
- Affinity Labels
- Amino Acid Sequence
- Binding Sites
- Carrier Proteins
- Computer Graphics
- Crystallization
- Crystallography, X-Ray
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Enzyme Activation
- Hydrogen Bonding
- Intracellular Signaling Peptides and Proteins
- Models, Molecular
- Molecular Sequence Data