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Article

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.

Science (New York, N.Y.) - 11 Aug 1995

Su Y, Dostmann W R, Herberg F W, Durick K, Xuong N H, Ten Eyck L, Taylor S S, Varughese K I

Abstract excerpt

In the molecular scheme of living organisms, adenosine 3',5'-monophosphate (cyclic AMP or cAMP) has been a universal second messenger. In eukaryotic cells, the primary receptors for cAMP are the regulatory subunits of cAMP-dependent protein kinase. The crystal structure of a 1-91 deletion mutant of the type I alpha regulatory subunit was refined to 2.8 A resolution. Each of the two tandem cAMP binding domains...

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PMID: 7638597
DOI: 10.1126/science.7638597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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