Article
Key amino acid residue in Melanocortin-1 receptor (melanocyte α-MSH receptor) for ligand selectivity.
Molecular and cellular endocrinology - 15 Oct 2017
Yang Yingkui, Chen Min, Ventro George, Harmon Carroll M
Abstract excerpt
The melanocortin-1 receptor (MC1R) is a subtype of the melanocortin receptor family and NDP-α-MSH is a non-selective agonist for MC1R. The core sequence of NDP-α-MSH, His-Phe-Arg-Trp, is important for ligand binding and biological activities at the melanocortin receptor subtypes (MCRs). A recent study indicates that Trp9 in NDP-α-MSH plays an important role in ligand selectivity. Deletion of Trp9 in NDP-α-MSH...
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