Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Basis of MC1R Activation: Mutation-Induced Alterations in Structural Dynamics.

Proteins - 1 Nov 2024

Cavatão Fernando Guimarães, Pinto Éderson Sales Moreira, Krause Mathias J, Alho Clarice Sampaio, Dorn Marcio

Abstract excerpt

The MC1R protein is a receptor found in melanocytes that plays a role in melanin synthesis. Mutations in this protein can impact hair color, skin tone, tanning ability, and increase the risk of skin cancer. The MC1R protein is activated by the alpha-melanocyte-stimulating hormone (α-MSH). Previous studies have shown that mutations affect the interaction between MC1R and α-MSH; however, the mechanism behind this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-MSH
Share to Binding Sites
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Molecular Dynamics Simulation

Share to Protein Binding

Share to Protein Conformation

Share to Receptor, Melanocortin, Type 1

Source

Identifiers

PMID: 38923677
DOI: 10.1002/prot.26722

Genes

MC1R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Basis of MC1R Activation: Mutation-Induced Alterations in Structural Dynamics.PMID 38923677Read ↗

Molecular Analysis and Conformational Dynamics of Human MC4R Disease-Causing Mutations.Semantic proximity Read ↗

Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.Semantic proximity Read ↗

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.Semantic proximity Read ↗

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.Semantic proximity Read ↗

A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor.Semantic proximity Read ↗

Activation of the cAMP pathway by variant human MC1R alleles expressed in HEK and in melanoma cells.Semantic proximity Read ↗

High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discoverySemantic proximity Read ↗

Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair.Semantic proximity Read ↗

Impact of homozygosity of R151C variant of MC1r in human hair follicle melanocytes.Semantic proximity Read ↗

Regulation of human melanocortin 1 receptor signaling and trafficking by Thr-308 and Ser-316 and its alteration in variant alleles associated with red hair and skin cancer.Semantic proximity Read ↗

Prediction of the damage-associated non-synonymous single nucleotide polymorphisms in the human MC1R gene.Semantic proximity Read ↗

Characterisation of D117A and H260A mutations in the melanocortin 1 receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.