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Article

APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces.

Journal of molecular biology - 17 Aug 2018

Salamango Daniel J, McCann Jennifer L, Demir Özlem, Brown William L, Amaro Rommie E, Harris Reuben S

Abstract excerpt

The APOBEC3 family of cytosine deaminases catalyzes the conversion of cytosines-to-uracils in single-stranded DNA. Traditionally, these enzymes are associated with antiviral immunity and restriction of DNA-based pathogens. However, a role for these enzymes in tumor evolution and metastatic disease has also become evident. The primary APOBEC3 candidate in cancer mutagenesis is APOBEC3B (A3B) for three reasons: (1)...

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Identifiers

PMID: 29787764
DOI: 10.1016/j.jmb.2018.04.044
PMCID: PMC6456046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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