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Article

In silico analyses of deleterious missense SNPs of human apolipoprotein E3.

Scientific reports - 30 May 2017

Pires Allan S, Porto William F, Franco Octavio L, Alencar Sérgio A

Abstract excerpt

ApoE3 is the major chylomicron apolipoprotein, binding in a specific liver peripheral cell receptor, allowing transport and normal catabolism of triglyceride-rich lipoprotein constituents. Point mutations in ApoE3 have been associated with Alzheimer's disease, type III hyperlipoproteinemia, atherosclerosis, telomere shortening and impaired cognitive function. Here, we evaluate the impact of missense SNPs in APOE...

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Share to Apolipoprotein E3
Share to Apolipoproteins E
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Dynamics Simulation

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to Protein Binding

Share to Structure-Activity Relationship

Source

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Identifiers

PMID: 28559539
DOI: 10.1038/s41598-017-01737-w
PMCID: PMC5449402

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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