Article
Spermatogonial deubiquitinase USP9X is essential for proper spermatogenesis in mice.
Reproduction (Cambridge, England) - 1 Aug 2017
Kishi Kasane, Uchida Aya, Takase Hinako M, Suzuki Hitomi, Kurohmaru Masamichi, Tsunekawa Naoki, Kanai-Azuma Masami, Wood Stephen A, Kanai Yoshiakira
Abstract excerpt
USP9X (ubiquitin-specific peptidase 9, X chromosome) is the mammalian orthologue of Drosophila deubiquitinase fat facets that was previously shown to regulate the maintenance of the germ cell lineage partially through stabilizing Vasa, one of the widely conserved factors crucial for gametogenesis. Here, we demonstrate that USP9X is expressed in the gonocytes and spermatogonia in mouse testes from newborn to adult...
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