Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal

30 May 2014

Abstract excerpt

Spermatogonial stem cells (SSCs) undergo self-renewal divisions to support spermatogenesis throughout life. Although several positive regulators of SSC self-renewal have been discovered, little is known about the negative regulators. Here, we report that F-box and WD-40 domain protein 7 (FBXW7), a component of the Skp1-Cullin-F-box-type ubiquitin ligase, is a negative regulator of SSC self-renewal. FBXW7 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24879440
DOI: 10.1073/pnas.1401837111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewalPMID 24879440Read ↗

Spermatogonial stem cells: A story of self-renewal and differentiationSemantic proximity Read ↗

MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteinsSemantic proximity Read ↗

Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammalsSemantic proximity Read ↗

Spermatogonial stem cells, infertility and testicular cancerSemantic proximity Read ↗

Roles of Spermatogonial Stem Cells in Spermatogenesis and Fertility RestorationSemantic proximity Read ↗

USP11 regulates proliferation and apoptosis of human spermatogonial stem cells via HOXC5-mediated canonical WNT/β-catenin signaling pathwaySemantic proximity Read ↗

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicingSemantic proximity Read ↗

BMI1 promotes spermatogonial stem cell maintenance by epigenetically repressing Wnt10b/β-catenin signalingSemantic proximity Read ↗

Regulation of spermatogonial stem cell self-renewal in mammals.Semantic proximity Read ↗

The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice.Semantic proximity Read ↗

Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage ResponseSemantic proximity Read ↗

Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.