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Article

Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis

5 Feb 2016

Abstract excerpt

CUL4B ubiquitin ligase belongs to the cullin-RING ubiquitin ligase family. Although sharing many sequence and structural similarities, CUL4B plays distinct roles in spermatogenesis from its homologous protein CUL4A. We previously reported that genetic ablation ofCul4ain mice led to male infertility because of aberrant meiotic progression. In the present study, we generated Cul4bgerm cell-specific conditional...

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PMID: 26846852
DOI: 10.1074/jbc.m115.699660

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