Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Current understanding of the interplay between catechol-O-methyltransferase genetic variants, sleep, brain development and cognitive performance in schizophrenia.

CNS & neurological disorders drug targets - 1 May 2012

Tucci Valter, Lassi Glenda, Kas Martien J

Abstract excerpt

Abnormal sleep is an endophenotype of schizophrenia. Here we provide an overview of the genetic mechanisms that link specific sleep physiological processes to schizophrenia-related cognitive defects. In particular, we will review the possible relationships between catechol-O-methyltransferase (COMT), sleep regulation and schizophrenia development. Recent studies validate the hypothesis that COMT mutations may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition

Share to Dopamine

Share to Genetic Variation

Share to Schizophrenia

Share to Schizophrenic Psychology

Source

Identifiers

PMID: 22483299
DOI: 10.2174/187152712800672454

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Current understanding of the interplay between catechol-O-methyltransferase genetic variants, sleep, brain development and cognitive performance in schizophrenia.PMID 22483299Read ↗

The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.Semantic proximity Read ↗

Catechol-O-methyltransferase gene promoter methylation as a peripheral biomarker in male schizophrenia.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.Semantic proximity Read ↗

Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders.Semantic proximity Read ↗

Sex-dichotomous effects of functional COMT genetic variations on cognitive functions disappear after menopause in both health and schizophrenia.Semantic proximity Read ↗

Adolescence is the starting point of sex-dichotomous COMT genetic effects.Semantic proximity Read ↗

Effects of COMT polymorphisms on brain function and behavior in health and disease.Semantic proximity Read ↗

Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children.Semantic proximity Read ↗

Prefrontal neurons and the genetics of schizophrenia.Semantic proximity Read ↗

Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.Semantic proximity Read ↗

Diverse facets of COMT: from a plausible predictive marker to a potential drug target for schizophrenia.Semantic proximity Read ↗

Imaging genetics of schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.