Article

Geometric Brain Signatures for Diagnosing Rare Hereditary Ataxias and Predicting Function

2026-03-09

Abstract excerpt

<h4>Background</h4> Hereditary cerebellar ataxias (HCAs) are rare neurodegenerative disorders characterised by progressive motor impairment and overlapping clinical phenotypes. Although genetic testing provides etiological diagnosis, diagnostic delays frequently arise before targeted testing, owing to non-specific presentation and limited clinician familiarity. Imaging-derived biomarkers that capture phenotypic e...

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Literature Corpus work: e5f833d1-a228-504d-a9bc-d3aa160ef31c
DOI: 10.64898/2026.03.08.26347882

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