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Article

The regioselective glucuronidation of morphine by dimerized human UGT2B7, 1A1, 1A9 and their allelic variants.

Acta pharmacologica Sinica - 1 Aug 2017

Yang Zi-Zhao, Li Li, Wang Lu, Yuan Ling-Min, Xu Ming-Cheng, Gu Jing-Kai, Jiang Hui-di, Yu Lu-Shan, Zeng Su

Abstract excerpt

Uridine diphosphate-glucuronosyltransferase (UGT) 2B7 is expressed mostly in the human liver, lung and kidney and can transfer endogenous glucuronide group into its substrate and impact the pharmacological effects of several drugs such as estriol, AZT and morphine. UGT2B7 and its allelic variants can dimerize with the homologous enzymes UGT1A1 and UGT1A9, as well as their allelic variants, and then change their...

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Identifiers

PMID: 28552915
DOI: 10.1038/aps.2016.157
PMCID: PMC5547550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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