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Article

The effects of N-glycosylation on the glucuronidation of zidovudine and morphine by UGT2B7 expressed in HEK293 cells.

Drug metabolism and pharmacokinetics - 1 Jan 2012

Nagaoka Kenjiro, Hanioka Nobumitsu, Ikushiro Shinichi, Yamano Shigeru, Narimatsu Shizuo

Abstract excerpt

UDP-glucuronosyltransferases (UGTs) are glycoproteins in endoplasmic reticulum membranes. UGT2B7 is an important UGT isoenzyme expressed in human liver and glucuronidates various endogenous and exogenous substances. Although this enzyme has three potential N-glycosylation sites (asparagine at positions 67, 68 and 315), no information is available on the actual glycosylated sites and the effects of N-glycosylation...

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Source

Identifiers

PMID: 22240840
DOI: 10.2133/dmpk.dmpk-11-rg-135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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