Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen.

Biochemical pharmacology - 1 Dec 2011

Wang Haina, Yuan Lingmin, Zeng Su

Abstract excerpt

Flurbiprofen (FPF), available commercially as a racemic mixture, is a propionic acid derivative of non-steroidal anti-inflammatory drugs (NSAIDs) with known stereoselective glucuronidation. The major enzyme catalyzing this conjugation reaction is UDP-glucuronosyltransferase (UGT) 2B7, with minor contributions by UGT1A9. This study examines the role of the genetic variants of UGT2B7 and 1A9 enzymes involved in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Glucuronides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronosyltransferase

Share to Polymorphism, Single Nucleotide

Share to Stereoisomerism

Share to UDP-Glucuronosyltransferase 1A9

Source

Identifiers

PMID: 21856293
DOI: 10.1016/j.bcp.2011.08.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen.PMID 21856293Read ↗

Use of Phenotypically Poor Metabolizer Individual Donor Human Liver Microsomes To Identify Selective Substrates of UGT2B10.Semantic proximity Read ↗

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S).Semantic proximity Read ↗

The regioselective glucuronidation of morphine by dimerized human UGT2B7, 1A1, 1A9 and their allelic variants.Semantic proximity Read ↗

Enzymatic activity of 38 CYP2C9 genotypes on ibuprofen.Semantic proximity Read ↗

Homo- and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity.Semantic proximity Read ↗

Identification of New Substrates and Inhibitors of Human CYP2A7.Semantic proximity Read ↗

UGT pharmacogenomicsSemantic proximity Read ↗

Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevanceSemantic proximity Read ↗

Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance.Semantic proximity Read ↗

Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors.Semantic proximity Read ↗

The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human DiseasesSemantic proximity Read ↗

Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.