Article
Expression of Phosphoinositide 3-Kinase p110α and p110β Subunits and PIK3CA Mutation in Patients With Advanced Gastric Carcinoma.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2000
Kim Kyungeun, Lee Hyoun Wook
Abstract excerpt
Activation of phosphoinositide 3-kinase (PI3K) is pivotal for the activity of the oncogenic PI3K/AKT signaling pathway. This study assessed the expression of 2 PI3K isoform proteins, p110α and p110β, and PIK3CA mutational status in advanced gastric carcinoma (AGC) and their correlation with clinicopathologic factors. Tissue microarray blocks were generated from 99 AGCs and immunohistochemically stained for p110α...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
