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Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma

23 May 2017

Abstract excerpt

Cholangiocarcinoma is an epithelial malignancy arising in the region between the intrahepatic bile ducts and the ampulla of Vater at the distal end of the common bile duct. The effect of current chemotherapy regimens against cholangiocarcinoma is limited, and the prognosis of patients with cholangiocarcinoma is poor. Aberrant DNA methylation and histone modification induce silencing of tumor suppressor genes and...

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PMID: 28545228
DOI: 10.3390/ijms18061111

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