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Genetic and epigenetic changes associated with cholangiocarcinoma: From DNA methylation to microRNAs

1 Jan 2007

Abstract excerpt

Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an integral role in the neoplastic transformation of human cells to their malignant counterparts. This review summarizes...

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PMID: 18161915
DOI: 10.3748/wjg.v13.i48.6465

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