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High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5

24 Dec 2014

Abstract excerpt

RIG-I and MDA5 are the major intracellular immune receptors that recognize viral RNA species and undergo a series of conformational transitions leading to the activation of the interferon-mediated antiviral response. However, to date, full-length RLRs have resisted crystallographic efforts and a molecular description of their activation pathways remains hypothetical. Here we employ hydrogen/deuterium exchange...

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PMID: 25539915
DOI: 10.1093/nar/gku1329

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