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Article

GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury.

Journal of the American Society of Nephrology : JASN - 1 Jun 2015

Huen Sarah C, Huynh Larry, Marlier Arnaud, Lee Yashang, Moeckel Gilbert W, Cantley Lloyd G

Abstract excerpt

After kidney ischemia/reperfusion (I/R) injury, monocytes home to the kidney and differentiate into activated macrophages. Whereas proinflammatory macrophages contribute to the initial kidney damage, an alternatively activated phenotype can promote normal renal repair. The microenvironment of the kidney during the repair phase mediates the transition of macrophage activation from a proinflammatory to a reparative...

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Share to Acute Kidney Injury
Share to Granulocyte-Macrophage Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Tubules, Proximal

Share to Macrophage Activation

Share to Multivariate Analysis

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Share to Real-Time Polymerase Chain Reaction

Share to Reperfusion Injury

Source

Open in PubMed Open full text

Identifiers

PMID: 25388222
DOI: 10.1681/ASN.2014060612
PMCID: PMC4446881

Genes

STAT3
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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