Article

Macrophage Migration Inhibitory Factor (MIF)-CD74 Signaling Pathway Mediates Trabecular Meshwork Dysfunction in Glaucoma

2026-03-20

Abstract excerpt

<h4>Purpose</h4> Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in many inflammatory and fibrotic diseases; however, its role in primary open-angle glaucoma (POAG) and trabecular meshwork (TM) dysfunction remains unknown. In this study, we investigated whether MIF-CD74 signaling regulates TM pathobiology through modulation of the transcription factor, Blimp-1, and downstream cyt...

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Literature Corpus work: 8e712c46-829a-5d1f-bc45-4d4e1e7cef66
DOI: 10.64898/2026.03.18.712673

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