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Article

Association of the C-344T polymorphism of CYP11B2 gene with essential hypertension in Hani and Yi minorities of China.

Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2006

Tang Wenru, Wu Hongyan, Zhou Xuhong, Cheng Baowen, Dong Yongli, He Li, Yu Haijing, Xu Lin, Lu Jing, Li Kaiyuan, Xiao Chunjie

Abstract excerpt

BACKGROUND: Aldosterone synthase (CYP11B2) is a key enzyme in the biosynthesis of aldosterone. Recently, a C-344T polymorphism in the promoter region of the CYP11B2 gene has been reported to be in association with high blood pressure. We investigated the association between this polymorphism and essential hypertension in Hani (n=305 individuals) and Yi (n=233 individuals) minorities of China. METHODS: CYP11B2...

Topics

Adult
Aged
Alleles
Case-Control Studies
Cytochrome P-450 CYP11B2
Female
Gene Frequency
Genotype
Humans
Hypertension
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 16126185
DOI: 10.1016/j.cccn.2005.07.006

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