Article
Haplotype-based case-control study of the human CYP11B2 gene and essential hypertension in Yi and Hani minorities of China.
Biochemical genetics - 1 Feb 2011
Chen Bifeng, Nie Shengjie, Yue Zhaoping, Shou Weihua, Xiao Chunjie
Abstract excerpt
This haplotype-based case-control study investigated whether the aldosterone synthase gene (CYP11B2) might be implicated in the pathogenesis of essential hypertension in Yi (226 individuals) and Hani (296 individuals) minorities of China. Four tag SNPs (rs4536, rs4545, rs3097, and rs3802230) and the K173R polymorphism were genotyped using the PCR-RFLP method. In the Hani minority, rs4536 was significantly...