Common polymorphism rs11191548 near the CYP17A1 gene is associated with hypertension and systolic blood pressure in the Han Chinese population.

doi:10.1093/ajh/hps066

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Article

Common polymorphism rs11191548 near the CYP17A1 gene is associated with hypertension and systolic blood pressure in the Han Chinese population.

American journal of hypertension - 1 Apr 2013

Li Xiaomu, Ling Yan, Lu Daru, Lu Zhiqiang, Liu Ying, Chen Hongyan, Gao Xin

Abstract excerpt

Background The single-nucleotide polymorphism (SNP) rs11191548, near the CYP17A1 gene, has been identified as being associated with hypertension and systolic blood pressure (SBP) in genome-wide association studies (GWAS) in a European population. The CYP17A1 gene encodes cytochrome P450c17alpha and plays an important role in the steroidogenic pathway, which includes mineralocorticoids. Methods We investigated the...

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PMID: 23467202
DOI: 10.1093/ajh/hps066

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