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Article

A novel haplotype of low-frequency variants in the aldosterone synthase gene among northern Han Chinese with essential hypertension.

Medicine - 1 Sept 2017

Zhang Hao, Li Xueyan, Zhou Li, Zhang Keyong, Zhang Qi, Li Jingping, Wang Ningning, Jin Ming, Wu Nan, Cong Mingyu, Qiu Changchun

Abstract excerpt

Low-frequency variants showed that there is more power to detect risk variants than to detect protective variants in complex diseases. Aldosterone plays an important role in the renin-angiotensin-aldosterone system, and aldosterone synthase catalyzes the speed-controlled steps of aldosterone biosynthesis. Polymorphisms of the aldosterone synthase gene (CYP11B2) have been reported to be associated with essential...

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PMID: 28953657
DOI: 10.1097/MD.0000000000008150
PMCID: PMC5626300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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