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A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF

15 Sept 2021

Abstract excerpt

Alveolar epithelial cell (AEC) senescence is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Mitochondrial dysfunction including release of mitochondrial DNA (mtDNA) is a feature of senescence, which led us to investigate the role of the DNA-sensing guanine monophosphate-adenine monophosphate (GMP-AMP) synthase (cGAS) in IPF, with a focus on AEC senescence. cGAS expression in fibrotic...

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PMID: 34524912
DOI: 10.1152/ajplung.00574.2020

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