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Hepatitis B Virus and DNA Damage Response: Interactions and Consequences for the Infection

19 Oct 2017

Abstract excerpt

Hepatitis B virus (HBV) is a major etiologic agent of acute and chronic hepatitis, and end-stage liver disease. Establishment of HBV infection, progression to persistency and pathogenesis are determined by viral and cellular factors, some of which remain still undefined. Key steps of HBV life cycle e.g., transformation of genomic viral DNA into transcriptionally active episomal DNA (cccDNA) or transcription of...

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PMID: 29048354
DOI: 10.3390/v9100304

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