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PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals

2 Apr 2020

Abstract excerpt

PIN1 is a phosphorylation-directed member of the peptidyl-prolyl cis/trans isomerase family that facilitates conformational changes in phosphorylated targets such as c-MYC (MYC). Following signaling events that mediate phosphorylation of MYC at Serine 62, PIN1 establishes structurally distinct pools of MYC through its trans-cis and cis-trans isomerization activity at Proline 63. Through these isomerization steps,...

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PMID: 32300594
DOI: 10.3389/fcell.2020.00224

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