Article

Differential response of the liver to bile acid treatment in a mouse model of Niemann-Pick disease type C

2018-04-04

Abstract excerpt

Niemann-Pick disease type C (NPC) disease is a neurodegenerative lysosomal storage disease caused by mutations in the NPC1 or NPC2 genes. Liver disease is also a common feature of NPC that can present as cholestatic jaundice in the neonatal period. Liver enzymes can remain elevated above the normal range in some patients as they age. <ns4:p/> We recently reported suppression of the P450 detoxification system i...

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Literature Corpus work: 9ccdf2ae-fa28-547d-bd0c-f9ce912480ed
DOI: 10.12688/wellcomeopenres.12431.2

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