Article
PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Jan 2012
Li Zhu, Chadalapaka Gayathri, Ramesh Aramandla, Khoshbouei Habibeh, Maguire Mark, Safe Stephen, Rhoades Raina E, Clark Ryan, Jules George, McCallister Monique, Aschner Michael, Hood Darryl B
Abstract excerpt
The wild-type (WT) Cpr(lox/lox) (cytochrome P(450) oxidoreductase, Cpr) mouse is an ideal model to assess the contribution of P(450) enzymes to the metabolic activation and disposition of environmental xenobiotics. In the present study, we examined the effect of in utero exposure to benzo(a)pyrene [B(a)P] aerosol on Sp4 and N-methyl-D-aspartate (NMDA)-dependent systems as well as a resulting behavioral phenotype...
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