Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse.

Toxicology and applied pharmacology - 1 Feb 2004

Engle Mark R, Singh Sharda P, Czernik Piotr J, Gaddy Dana, Montague Donna C, Ceci Jeffrey D, Yang Yusong, Awasthi Sanjay, Awasthi Yogesh C, Zimniak Piotr

Abstract excerpt

The lipid peroxidation product 4-hydroxynon-2-enal (4-HNE) is a strong electrophile that forms covalent adducts with proteins and, to a lesser extent, nucleic acids and phospholipids. The generation of 4-HNE appears to be an inevitable consequence of aerobic metabolism. The metabolism of 4-HNE is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Aldehydes
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Composition

Share to Bone Density

Share to Gene Library

Share to Glutathione Transferase

Share to Malondialdehyde

Source

Identifiers

PMID: 14761685
DOI: 10.1016/j.taap.2003.10.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14761685-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse.PMID 14761685Read ↗

Disruption of the mGsta4 gene increases life span of C57BL mice.Semantic proximity Read ↗

Genetically altered mice to evaluate glutathione homeostasis in health and disease.Semantic proximity Read ↗

Assessment of the mouse as an experimental model for studying polymorphic oxidation of the sparteine/debrisoquine type.Semantic proximity Read ↗

Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.Semantic proximity Read ↗

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain.Semantic proximity Read ↗

Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog.Semantic proximity Read ↗

S -Nitrosylation from GSNOR Deficiency Impairs DNA Repair and Promotes HepatocarcinogenesisSemantic proximity Read ↗

Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.Semantic proximity Read ↗

Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).Semantic proximity Read ↗

Catalytic function of Drosophila melanogaster glutathione S-transferase DmGSTS1-1 (GST-2) in conjugation of lipid peroxidation end products.Semantic proximity Read ↗

Disruption of the microsomal glutathione S-transferase-like gene reduces life span of Drosophila melanogaster.Semantic proximity Read ↗

Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.