Article
Biodistribution of, antimutagenic efficacies in Salmonella typhimurium of, and inhibition of P450 activities by ellagic acid and one analogue.
Chemical research in toxicology - 1 Nov 1998
Castonguay A, Boukharta M, Teel R
Abstract excerpt
Ellagic acid (EA) is generated by hydrolysis of ellagitannins present in fruit berries and edible nuts and grapes. Large doses of EA prevent lung tumorigenesis induced by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice. In this study, we document the effica...
Topics
- Animals
- Antimutagenic Agents
- Carcinogens
- Chromatography, High Pressure Liquid
- Cytochrome P-450 Enzyme Inhibitors
- Ellagic Acid
- Enzyme Inhibitors
- Lung
- Mice
- Mice, Inbred A
- Microsomes
- Mutation
- Nitrosamines
- Salmonella typhimurium
- Testosterone