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Article

The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.

Oncotarget - 18 Jul 2017

Solga Anne C, Toonen Joseph A, Pan Yuan, Cimino Patrick J, Ma Yu, Castillon Guillaume A, Gianino Scott M, Ellisman Mark H, Lee Da Yong, Gutmann David H

Abstract excerpt

Low-grade gliomas are one of the most common brain tumors in children, where they frequently form within the optic pathway (optic pathway gliomas; OPGs). Since many OPGs occur in the context of the Neurofibromatosis Type 1 (NF1) cancer predisposition syndrome, we have previously employed Nf1 genetically-engineered mouse (GEM) strains to study the pathogenesis of these low-grade glial neoplasms. In the light of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28525381
DOI: 10.18632/oncotarget.17589
PMCID: PMC5564557

Genes

GFAP
GEM

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