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Article

Temporal, spatial, and genetic constraints contribute to the patterning and penetrance of murine neurofibromatosis-1 optic glioma.

Neuro-oncology - 12 Apr 2021

Brossier Nicole M, Thondapu Sharanya, Cobb Olivia M, Dahiya Sonika, Gutmann David H

Abstract excerpt

BACKGROUND: Brain tumors are the most common solid tumors of childhood, but little is understood about the factors that influence their development. Pediatric low-grade gliomas in particular display unique temporal and spatial localization associated with different genetic mutations (eg, BRAF genomic alterations, mutations in the neurofibromatosis type 1 [NF1] gene) for reasons that remain unclear. NF1 low-grade...

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Identifiers

PMID: 33080011
DOI: 10.1093/neuonc/noaa237
PMCID: PMC8041339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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