Article
NF1 mutation drives neuronal activity-dependent initiation of optic glioma.
Nature - 1 Jun 2021
Pan Yuan, Hysinger Jared D, Barron Tara, Schindler Nicki F, Cobb Olivia, Guo Xiaofan, Yalçın Belgin, Anastasaki Corina, Mulinyawe Sara B, Ponnuswami Anitha, Scheaffer Suzanne, Ma Yu, Chang Kun-Che, Xia Xin, Toonen Joseph A, Lennon James J, Gibson Erin M, Huguenard John R, Liau Linda M, Goldberg Jeffrey L, Monje Michelle, Gutmann David H
Abstract excerpt
Neurons have recently emerged as essential cellular constituents of the tumour microenvironment, and their activity has been shown to increase the growth of a diverse number of solid tumours1. Although the role of neurons in tumour progression has previously been demonstrated2, the importance of neuronal activity to tumour initiation is less clear-particularly in the setting of cancer predisposition syndromes....
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