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Article

The impact of coexisting genetic mutations on murine optic glioma biology.

Neuro-oncology - 1 May 2015

Kaul Aparna, Toonen Joseph A, Gianino Scott M, Gutmann David H

Abstract excerpt

BACKGROUND: Children with the neurofibromatosis type 1 (NF1) tumor predisposition syndrome are prone to the development of optic pathway gliomas resulting from biallelic inactivation of the NF1 gene. Recent studies have revealed the presence of other molecular alterations in a small portion of these NF1-associated brain tumors. The purpose of this study was to leverage Nf1 genetically engineered mouse strains to...

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Source

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Identifiers

PMID: 25246427
DOI: 10.1093/neuonc/nou287
PMCID: PMC4482850

Genes

GFAP
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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