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Article

Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia.

Proceedings of the National Academy of Sciences of the United States of America - 8 Nov 2011

Chauhan Bharesh K, Lou Ming, Zheng Yi, Lang Richard A

Abstract excerpt

Epithelial bending is a central feature of morphogenesis in animals. Here we show that mutual antagonism by the small Rho GTPases Rac1 and RhoA determines cell shape, tissue curvature, and invagination activity in the model epithelium of the developing mouse lens. The epithelial cells of the invaginating lens placode normally elongate and change from a cylindrical to an apically constricted, conical shape. RhoA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22021442
DOI: 10.1073/pnas.1108993108
PMCID: PMC3215052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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