The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.

doi:10.1242/dev.00304

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Article

The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.

Development (Cambridge, England) - 1 Feb 2003

Fanto Manolis, Clayton Lesley, Meredith Jamie, Hardiman Kirsten, Charroux Bernard, Kerridge Stephen, McNeill Helen

Abstract excerpt

Fat is an atypical cadherin that controls both cell growth and planar polarity. Atrophin is a nuclear co-repressor that is also essential for planar polarity; however, it is not known what genes Atrophin controls in planar polarity, or how Atrophin activity is regulated during the establishment of planar polarity. We show that Atrophin binds to the cytoplasmic domain of Fat and that Atrophin mutants show strong...

Topics

Animals
Cell Adhesion Molecules
Cell Differentiation
Cell Nucleus
Cell Polarity
Cytoplasm
Drosophila
Drosophila Proteins
Eye
Eye Abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Expression Regulation, Developmental

Genes, Tumor Suppressor

Male

Membrane Glycoproteins

Mutation

Photoreceptor Cells, Invertebrate

Protein Structure, Tertiary

Source

Open in PubMed

Identifiers

PMID: 12506006
DOI: 10.1242/dev.00304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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