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Article

Prickle/spiny-legs isoforms control the polarity of the apical microtubule network in planar cell polarity.

Development (Cambridge, England) - 1 Jul 2014

Olofsson Jessica, Sharp Katherine A, Matis Maja, Cho Bomsoo, Axelrod Jeffrey D

Abstract excerpt

Microtubules (MTs) are substrates upon which plus- and minus-end directed motors control the directional movement of cargos that are essential for generating cell polarity. Although centrosomal MTs are organized with plus-ends away from the MT organizing center, the regulation of non-centrosomal MT polarity is poorly understood. Increasing evidence supports the model that directional information for planar...

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Identifiers

PMID: 25005476
DOI: 10.1242/dev.105932
PMCID: PMC4197621

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