Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane.

doi:10.1093/mutage/gex014

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Article

Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane.

Mutagenesis - 1 Jul 2017

Akiba Nozomi, Shiizaki Kazuhiro, Matsushima Yoshitaka, Endo Osamu, Inaba Kazuho, Totsuka Yukari

Abstract excerpt

It has been suggested that dichloromethane (DCM) and 1,2-dichloropropane (DCP) are responsible for occupational cholangiocarcinoma. Dihaloalkanes are metabolically activated by GSH S-transferase theta1 (GSTT1) to yield products such as episulfonium ions. However, whether the GSTT1-mediated step of these dihaloalkanes is related to occupational cholangiocarcinoma is not known. In the present study, we investigated...

Topics

DNA Adducts
DNA Mutational Analysis
DNA, Bacterial
Glutathione Transferase
Humans
Methylene Chloride
Mutagenesis
Mutagens
Mutation
Propane
Salmonella typhimurium

Source

Open in PubMed

Identifiers

PMID: 28521016
DOI: 10.1093/mutage/gex014

Genes

GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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