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Article

Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane.

Mutagenesis - 1 Jul 2017

Akiba Nozomi, Shiizaki Kazuhiro, Matsushima Yoshitaka, Endo Osamu, Inaba Kazuho, Totsuka Yukari

Abstract excerpt

It has been suggested that dichloromethane (DCM) and 1,2-dichloropropane (DCP) are responsible for occupational cholangiocarcinoma. Dihaloalkanes are metabolically activated by GSH S-transferase theta1 (GSTT1) to yield products such as episulfonium ions. However, whether the GSTT1-mediated step of these dihaloalkanes is related to occupational cholangiocarcinoma is not known. In the present study, we investigated...

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Identifiers

PMID: 28521016
DOI: 10.1093/mutage/gex014

Genes

GSTT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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