Article
Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain.
Environmental health perspectives - 1 Nov 2010
Cantor Kenneth P, Villanueva Cristina M, Silverman Debra T, Figueroa Jonine D, Real Francisco X, Garcia-Closas Monserrat, Malats Nuria, Chanock Stephen, Yeager Meredith, Tardon Adonina, Garcia-Closas Reina, Serra Consol, Carrato Alfredo, Castaño-Vinyals Gemma, Samanic Claudine, Rothman Nathaniel, Kogevinas Manolis
Abstract excerpt
BACKGROUND: Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water. OBJECTIVES: In this study we investigated the combined influence of DBP exposure and polymorphisms in glutathione S-transferase (GSTT1, GSTZ1) and cytochrome P450 (CYP2E1) genes in the metabolic pathways of selected by-products on bladder cancer in a hospital-based case-control study in Spain....
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