Article
GSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progression.
PloS one - 1 Jan 2014
Yang Fan, Xiong Jie, Jia Xiao-E, Gu Zhao-Hui, Shi Jing-Yi, Zhao Yan, Li Jun-Min, Chen Sai-Juan, Zhao Wei-Li
Abstract excerpt
The interrelationship between genetic susceptibility and carcinogenic exposure is important in cancer development. Polymorphisms in detoxification enzymes of the glutathione-S-transferases (GST) family are associated with an increased incidence of lymphoma. Here we investigated the molecular connection of the genetic polymorphism of GSTT1 to the response of lymphocytes to polycyclic aromatic hydrocarbons (PAH)....
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