Article
The essential role of GSTP1 I105V polymorphism in the prediction of CDNB metabolism and toxicity: In silico and in vitro insights.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Aug 2023
Lin Hao, Wu Han, Li Hengda, Song Aoqi, Yin Wu
Abstract excerpt
Humans are continuously exposed to toxic chemicals such as nitro-chlorobenzene (CDNB) through occupation, water, and even the air we breathe. Due to the severe toxicity caused by the high electrophilicity of CDNB, occupational and environmental exposure to CDNB can produce toxic effects that ultimately lead to cell damage. CDNB can be eliminated from organisms by binding to GSH, the catalytic product of...
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