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Article

Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variants.

European journal of biochemistry - 1 Jul 2001

Gisi D, Maillard J, Flanagan J U, Rossjohn J, Chelvanayagam G, Board P G, Parker M W, Leisinger T, Vuilleumier S

Abstract excerpt

Methylobacterium dichloromethanicum DM4 is able to grow with dichloromethane as the sole carbon and energy source by using a dichloromethane dehalogenase/glutathione S-transferase (GST) for the conversion of dichloromethane to formaldehyde. Mammalian homologs of this bacterial enzyme are also known to catalyze this reaction. However, the dehalogenation of dichloromethane by GST T1-1 from rat was highly mutagenic...

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Identifiers

PMID: 11453994
DOI: 10.1046/j.1432-1327.2001.02314.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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