Article
Statin Use After Diagnosis of Colon Cancer and Patient Survival.
Gastroenterology - 1 Aug 2017
Voorneveld Philip W, Reimers Marlies S, Bastiaannet Esther, Jacobs Rutger J, van Eijk Ronald, Zanders Marjolein M J, Herings Ron M C, van Herk-Sukel Myrthe P P, Kodach Liudmila L, van Wezel Tom, Kuppen Peter J K, Morreau Hans, van de Velde Cornelis J H, Hardwick James C H, Liefers Gerrit Jan
Abstract excerpt
BACKGROUND & AIMS: Statin use has been associated with a reduced incidence of colorectal cancer and might also affect survival of patients diagnosed with colon cancer. Statins are believed to inhibit Ras signaling and may also activate the bone morphogenetic protein (BMP) signaling pathway in colorectal cancer cells. We investigated the effects of statins on overall survival of patients with a diagnosis of colon...
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