Article
Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer.
JAMA internal medicine - 1 May 2014
Reimers Marlies S, Bastiaannet Esther, Langley Ruth E, van Eijk Ronald, van Vlierberghe Ronald L P, Lemmens Valery E P, van Herk-Sukel Myrthe P P, van Wezel Tom, Fodde Riccardo, Kuppen Peter J K, Morreau Hans, van de Velde Cornelis J H, Liefers Gerrit Jan
Abstract excerpt
IMPORTANCE: Use of aspirin (which inhibits platelet function) after a colon cancer diagnosis is associated with improved overall survival. Identifying predictive biomarkers of this effect could individualize therapy and decrease toxic effects. OBJECTIVE: To demonstrate that survival benefit associated with low-dose aspirin use after a diagnosis of colorectal cancer might depend on HLA class I antigen expression....
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